Early in the forth century, the Greek mathematician Pepose declared that the smart shape of honeycomb is the representative of the most effective labor of the nature. At that time, he guessed “The hexagon honeycomb which mankind can see is made with the least beeswax.” This guess is known as “honeycomb guess.”

Darwin, the famous biologist even insisted “the man must be muddle-headed if he does not pay double tribute when he sees the honeycomb.”